The suspects left the bank with cash, and were last seen on foot in the area of North Church Street.
Surveillance photographs show the suspects, a black male with a gray beard wearing a white t-shirt, baseball cap, and sunglasses, and a white woman with shoulder length brown hair wearing a zippered hooded sweatshirt.
Anyone with information related to the incident is asked to call the Berryville Police Department at (540) 955-3963 or (540) 955-1234. The incident is being jointly investigated by the Berryville Police Department and the F.B.I.
Anyone with information can also call the Winchester-Frederick-Clarke Crime Solvers at (540) 665-TIPS.
Copyright 2017 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.