Hancock Police stopped the van Wednesday Night on Interstate 70. East Tennessee Police issued an Amber Alert when the children went missing, and they are now safe and in the custody of Washington County Child Services.
Police say Jeremy Knasel and Ashley Norberg took the children from their grandparents.
Knasel and Norberg are accused of manufacturing meth inside their home, and police also believe the two were armed with a handgun
The Tennessee FBI will now continue to handle the case.
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