Pennsylvania State Police Chambersburg Barracks say the crash happened around 5:36 a.m. along Lincoln Way East, near Cameo Drive.
Troopers say Clarie Elisabeth Cody, 35, of Orrtanna, Pa., was driving westbound on Lincoln Way East when she crossed the eastbound lane and traveled onto the south shoulder of the roadway striking a speed limit sign.
Police say Cody then continued westbound into the eastbound lane and struck a vehicle head-on, driven by Edward E. Naugle Jr., 78, of Fayetteville.
Naugle died as a result of the crash.
State police say the investigation is ongoing.
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