The crash happened just a couple miles south of Junction Virginia 48 around 6:30 a.m. Friday morning.
All north and southbound lanes were shut down just before 11 a.m. Friday, as Virginia State Police remained on the scene conducting accident reconstruction.
Shenandoah Valley Fire's Facebook page reported that a helicopter was on scene and flew one patient to Winchester Medical Center. The second person was taken to the hospital by ambulance.
The extent of the their injuries are unknown at this time.
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