It happened around along I-81 near mile marker 18, just between exits 16 and 20.
Fire and rescue officials say the vehicle overturned, leaking fuel onto the road. They say the trailer’s load, a Grove crane, was blocking the northbound lanes.
Wreckers were called in to remove the crane near the northbound lanes.
No injuries were reported.
The northbound lanes of I-81 were officially reopened around 10:30 p.m. Monday night.