It happened at the intersection of Tasker Road and Warrior Drive around 7:30 a.m. Wednesday morning.
A head-on collision left one car in a ditch on its side. One of the students was okay, but due to the instability of the car that person was unable to escape.
Officials say the two high school students, one male and female, were taken to Winchester Medical Center.
As of right now, we are not aware of their conditions.